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| Product Datasheet |
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| Product Name |
Gallidermin |
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| Product number |
SgG-95-01 |
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| Product type |
Peptide, Lantibiotic |
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| Source |
Staphylococcus gallinarum Tü3298 |
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Description |
Chromatographically or HPLC purified peptide of high purity and activity from a wild type S. gallinarum strain. Peptide size is 2164 Da. |
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| Solubility |
Gallidermin is soluble e.g. in water, ethanol, methanol (1 mg/ml) |
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Relevance |
It
is a natural antimicrobial peptide, which belongs to the class of
'lantibiotics' and is active against many Gram-positive pathogens.
It is active towards both growing as well as non-dividing bacteria. No cross resistance to Methicillin, Tetracycline, Vancomycin, Erythromycin, Clindamycin, or other lantibiotics such as Nisin. Mode of action:- Interference with the biosynthesis of the bacterial cell wall. - Formation of non-specific transmembrane pores in an energy-dependent fashion Intended applications:· Treatment of multidrug resistant strains of Staphylococcus aureus · cosmetic preservation · protective against Propionibacterium acnes, involved in certain forms of acne disease |
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| Storage buffer |
- |
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| Form |
white Powder (Lyophilized) |
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| Storage instructions |
Store dry at 4°C |
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| Purification notes |
Chromatographically purified. Appears as a single peak in HPLC analysis. |
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| Safety Notes |
For research use only! Not intended for diagnostic or therapeutic use! Do not breathe dust! |
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| References |
Kellner, R., Jung, G., Hörner, T., Zähner, H., Schnell, N., Entian, K.-D., and Götz, F. (1988). Gallidermin: a new lanthionine containing polypeptide antibiotic. Eur. J. Biochem. 177: 53-59. Kempf, M., Theobald, U. and Fiedler, H.-P. (1999) Economic improvement of the fermentative production of gallidermin by Staphylococcus gallinarum. Biotechnol. Letters 21: 663-667. Kupke, T., and Götz, F. (1996). Post-translational modification of lantibiotics. Antonie van Leeuwenhoek 69: 139-150. |
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